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Article

ClpP Protease, a Promising Antimicrobial Target

7 May 2019

Abstract excerpt

The caseinolytic protease proteolytic subunit (ClpP) is a serine protease playing an important role in proteostasis of eukaryotic organelles and prokaryotic cells. Alteration of ClpP function has been proved to affect the virulence and infectivity of a number of pathogens. Increased bacterial resistance to antibiotics has become a global problem and new classes of antibiotics with novel mechanisms of action are...

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PMID: 31067645
DOI: 10.3390/ijms20092232

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