Article

Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene <i>Htra1</i>

2024-04-15

Abstract excerpt

Major depressive disorder (MDD) is linked to impaired structural and synaptic plasticity in limbic brain regions. Astrocytes, which regulate synapses and are influenced by chronic stress, likely contribute to these changes. We analyzed astrocyte gene profiles in the nucleus accumbens (NAc) of humans with MDD and mice exposed to chronic stress. Htra1 , which encodes an astrocyte-secreted protease targeting the ext...

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Literature Corpus work: 50286d0f-5cf4-5a2c-87c6-c51d57e260fe
DOI: 10.1101/2024.04.12.588724

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