Article

E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial Hypertension

2026-07-07

Abstract excerpt

<h4>Background</h4> Pulmonary arterial hypertension (PAH) is driven by maladaptive endothelial remodeling, but the transcriptional regulators that couple proliferative stress to arterialized endothelial states remain incompletely defined. E2F transcription factor 1 (E2F1) is classically viewed as a cell-cycle regulator; whether E2F1 functions as a disease-driving node that promotes endothelial arterial programmin...

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Literature Corpus work: 34e25d9f-5982-575d-880b-dd7f8d64860c
DOI: 10.64898/2026.07.02.736230

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