Article

Repression of CB1 receptor gene expression caused by dysfunctional microRNAs contributes to simvastatin-induced skeletal muscle cell toxicity

2022-07-22

Abstract excerpt

<h4>Background: </h4> and Purpose Statins are the most common prescribed lipid-lowering agents worldwide. Although their use is generally safe, statins cause muscle disorders in 1 in 10.000 people. In this study, we investigated the role of the endocannabinoid system (ECS) in statin-induced myotoxicity. Experimental Approach ECS activity was evaluated in murine C2C12 and primary human myoblasts exposed to simvasta...

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Literature Corpus work: 1a67b174-1fc5-5c42-864d-60bd97afc71b
DOI: 10.22541/au.165848783.38072785/v1

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