Article

Selective induction by statins of FAM134B-mediated sarcoplasmic reticulum (SR)-phagy degrades the SR calcium pump SERCA1 and contributes to myopathy

2025-12-01

Abstract excerpt

<h4>Summary</h4> Statins, HMG-CoA reductase inhibitors, are the most prescribed medication for lowering low-density lipoprotein cholesterol. Although statin intolerance due to statin-associated muscle symptoms (SAMS) has been a clinically important issue for decades, the molecular mechanisms of statin myopathy remain incompletely understood. To seek to clarify how statins induce myopathy, here we perform transcri...

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Literature Corpus work: 2628aba1-6b9b-53ed-a3a0-b15c9eff9d63
DOI: 10.1101/2025.11.26.690680

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