Article
Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation.
The Journal of clinical investigation - 15 Dec 2025
Weninger Gunnar, Dridi Haikel, Reiken Steven, Yuan Qi, Zhao Nan, Groom Linda, Leigh Jennifer, Liu Yang, Tchagou Carl, Kang Jiayi, Chang Alexander, Luna-Figueroa Estefania, Miotto Marco C, Wronska Anetta, Dirksen Robert T, Marks Andrew R
Abstract excerpt
Statins lower cholesterol, reducing the risk of heart disease, and are among the most frequently prescribed drugs. Approximately 10% of individuals develop statin-associated muscle symptoms (SAMS; myalgias, rhabdomyolysis, and muscle weakness), often rendering them statin intolerant. The mechanism underlying SAMS remains poorly understood. Patients with mutations in the skeletal muscle ryanodine receptor 1...
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