Statin-associated muscle toxicity : clinical and genomic perspectives

Abstract excerpt

Statins are lipid-lowering agents and amongst the most commonly prescribed medications worldwide. Although generally well-tolerated, statins cause a range of adverse myotoxicity phenotypes ranging from mild myalgia to rare life-threatening rhabdomyolysis. The aetiology of statin-associated myotoxicity (SAM) is incompletely understood but clinical risk factors that increase systemic statin exposure (e.g. older age,...

Topics

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• Case-Control Studies
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Lipoproteins and Cardiovascular Health
• Liver-Specific Organic Anion Transporter 1
• Logistic Models
• Muscular Diseases
• Pharmacogenetics and Drug Metabolism
• Severity of Illness Index

Identifiers and source

Literature Corpus work

a5955fc6-c0c3-5d5c-b9c6-7c3e49355da8

DOI

10.17638/03020572