Back to search

Article

MicroRNA-mediated repression of endocannabinoid CB1 receptor expression contributes to simvastatin-induced skeletal muscle toxicity

2022-12-19

Abstract excerpt

<title>Abstract</title> <p>Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in 1 in 10.000 patients. In this study, we explored the role of the endocannabinoid system (ECS) during muscle toxicity induced by simvastatin. In murine C2C12 myoblasts exposed to simvastatin (30 µM), we found that the levels of the endocannabinoids 2-AG and A...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b62f3b36-97b8-5e01-97a4-915e9e00737d
DOI
10.21203/rs.3.rs-2328769/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
MicroRNA-mediated repression of endocannabinoid CB1 receptor expression contributes to simvastatin-induced skeletal muscle toxicityDOI 10.21203/rs.3.rs-2328769/v1
Repression of CB1 receptor gene expression caused by dysfunctional microRNAs contributes to simvastatin-induced skeletal muscle cell toxicitySemantic proximity
Selective induction by statins of FAM134B-mediated sarcoplasmic reticulum (SR)-phagy degrades the SR calcium pump SERCA1 and contributes to myopathySemantic proximity
Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle ComponentsSemantic proximity
Aaptamine Counteracts Statin-Induced PCSK9 Elevation to Improve LDL Receptor Expression and Cholesterol UptakeSemantic proximity
Simvastatin Influences Selected Aspects of Duchenne Muscular Dystrophy Pathology in a Mouse ModelSemantic proximity
Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophySemantic proximity
Muscular effects of statins in the elderly female: a review.Semantic proximity
Inhibition of the endocannabinoid system reverses obese phenotype in aged mice and partly restores skeletal muscle function.Semantic proximity
Statin-induced myopathy.Semantic proximity
Simvastatin Enhances Muscle Regeneration Through Autophagic Defect-Mediated Inflammation and mTOR Activation in G93ASOD1 Mice.Semantic proximity
Statin induced myotoxicity.Semantic proximity
Mechanism and effects of the skeletal muscle Nav1.4 inhibition by cannabidiolSemantic proximity
Select a neighboring publication to make it the new centre.