Article

Aaptamine Counteracts Statin-Induced PCSK9 Elevation to Improve LDL Receptor Expression and Cholesterol Uptake

2024-10-29

Abstract excerpt

<title>Abstract</title> <p>Atherosclerosis arises from lipid accumulation and plaque formation, primarily driven by elevated levels of LDL-cholesterol (LDL-C). PCSK9 plays a critical role by degrading LDL receptors (LDL-R), which are responsible for the clearance of LDL-C from the bloodstream. Consequently, inhibiting PCSK9 represents a promising strategy to enhance LDL-R expression and promote LDL-C uptake. Stat...

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Literature Corpus work: 2093ff8e-d787-50cc-abb0-e79e21e6162e
DOI: 10.21203/rs.3.rs-5292389/v1

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