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Genetic and pharmacological regulation of the endocannabinoid CB1 receptor in Duchenne muscular dystrophy

21 Sept 2018

Abstract excerpt

The endocannabinoid system refers to a widespread signaling system and its alteration is implicated in a growing number of human diseases. However, the potential role of endocannabinoids in skeletal muscle disorders remains unknown. Here we report the role of the endocannabinoid CB1 receptors in Duchenne's muscular dystrophy. In murine and human models, CB1 transcripts show the highest degree of expression at...

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PMID: 30262909
DOI: 10.1038/s41467-018-06267-1

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