Article

Re-evaluation of the Concept of Cancer Stem Cells and Cancer Stemness in the Light of Evolutionary Cancer Cell Biology (ECCB)

2024-06-17

Abstract excerpt

According to the ECCB, cancer represents the transition of a genomically damaged multicellular cell to a lower level of cell organization, controlled by the ancestral gene regulatory network (GRN) from the ancestral compartment of human and metazoan genomes. Cancer adopts ancient mechanisms and rules of the common ancestor, similar to those observed in parasitic amoebae. In cancer, the productive cell line generat...

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Literature Corpus work: 1a655d87-d13b-5871-896b-68782a1ae3c1
DOI: 10.20944/preprints202403.1158.v3

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