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Article

aCLS cancers: Genomic and epigenetic changes transform the cell of origin of cancer into a tumorigenic pathogen of unicellular organization and lifestyle.

Gene - 5 Feb 2020

Niculescu Vladimir F

Abstract excerpt

At least 1/3 of all acquired solid cancers produce unusual cyst-like structures (CLSs, PGCCs) with simultaneous loss of p53 function. However, p53 deficiency or accumulated mutations are not the causes of aCLS cancers. The cause is the reversal, to unicellularity, of a metabolic stressed cell by activating silenced transition switches and ancestral gene networks inherited from early Metazoans. After reprogramming...

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Identifiers

PMID: 31647999
DOI: 10.1016/j.gene.2019.144174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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