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Concise Reviews: Cancer Stem Cells: From Concept to Cure

30 Jul 2014

Abstract excerpt

In 1953, noting a remarkable consistency between the agents causing mutations and those associated with cancer, Carl Nordling, a Finnish-born architect, proposed that cancer results from an accumulation of genetic mutations. It is now generally accepted that inherited mutations and environmental carcinogens can lead to the development of premalignant clones. After further mutations, one cell reaches a critical...

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PMID: 25078632
DOI: 10.1002/stem.1798

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