Article

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementia

2025-10-15

Abstract excerpt

Ubiquilin-2 (UBQLN2) is a ubiquitin (Ub)-binding shuttle protein that is mutated in X-linked forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS/FTD-linked mutations in UBQLN2 disrupt its conformation, increasing its tendency to form cytoplasmic aggregates that may disrupt cellular regulation through loss-of-function (LOF) and gain-of-function (GOF) effects. To explore how ALS-assoc...

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Literature Corpus work: 1a64317e-d9ce-59bb-8a19-c0e78de0ece1
DOI: 10.1101/2025.10.15.682441

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