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Article

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration.

Nature neuroscience - 1 Apr 2026

Liu Yang, Huang Zhiyuan, Hsu Yu-Wen, Deme Pragney, Frankenfield Ashley M, Wu Suheng, Zhao Xiaofeng, Liu Honghe, Zhang Tao, Alexander Elizabeth J, Liu Mingming, Zhang Yanjun, Wang Haocheng, Zhou Yixin, Monteiro Mervyn J, Hao Ling, Haughey Norman J, Wang Jiou

Abstract excerpt

Protein homeostasis and lipid metabolism are essential processes frequently disrupted in neurodegenerative diseases. However, their mechanistic intersection in disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) remains unclear. Ubiquilin 2 (UBQLN2) is a protein quality control factor linked to ALS/FTD. Through multi-omic analyses of induced pluripotent stem cell (iPSC)-derived...

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Source

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Identifiers

PMID: 41912662
DOI: 10.1038/s41593-026-02226-y
PMCID: PMC13058728

Genes

UBQLN2
ALDH3A2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration.PMID 41912662Read ↗

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Broken Balance: Emerging Cross-Talk Between Proteostasis and Lipostasis in Neurodegenerative DiseasesSemantic proximity Read ↗

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