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Global proteomics of Ubqln2-based murine models of ALS

4 Dec 2020

Abstract excerpt

Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that act on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that binds the proteasome through its ubiquitin-like domain and is thought to deliver ubiquitinated proteins to proteasomes for degradation. UBQLN2 mutations result in...

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PMID: 33277362
DOI: 10.1074/jbc.ra120.015960

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