Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global proteomics of Ubqln2-based murine models of ALS

4 Dec 2020

Abstract excerpt

Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that act on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that binds the proteasome through its ubiquitin-like domain and is thought to deliver ubiquitinated proteins to proteasomes for degradation. UBQLN2 mutations result in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Endoplasmic Reticulum Stress and Disease
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33277362
DOI: 10.1074/jbc.ra120.015960

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global proteomics of Ubqln2-based murine models of ALSPMID 33277362Read ↗

Global proteomics of <i>Ubqln</i> 2-based murine models of ALSSemantic proximity Read ↗

TRIM9 and TRIM26 Interact with UBQLN2P497H to Modulate Its Proteasomal Degradation.Semantic proximity Read ↗

UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential.Semantic proximity Read ↗

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementiaSemantic proximity Read ↗

Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2.Semantic proximity Read ↗

UBQLN2 mutation causing heterogeneous X-linked dominant neurodegeneration.Semantic proximity Read ↗

Defective Proteasome Delivery of Polyubiquitinated Proteins by Ubiquilin-2 Proteins Containing ALS Mutations.Semantic proximity Read ↗

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutantsSemantic proximity Read ↗

Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in <i>UBQLN2</i> p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementiaSemantic proximity Read ↗

UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD.Semantic proximity Read ↗

Distribution of ubiquilin 2 and TDP-43 aggregates throughout the CNS in UBQLN2 p.T487I-linked amyotrophic lateral sclerosis and frontotemporal dementia.Semantic proximity Read ↗

Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.