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Article

Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2.

eLife - 11 Apr 2023

Kim Sang Hwa, Nichols Kye D, Anderson Eric N, Liu Yining, Ramesh Nandini, Jia Weiyan, Kuerbis Connor J, Scalf Mark, Smith Lloyd M, Pandey Udai Bhan, Tibbetts Randal S

Abstract excerpt

Mutations in the ubiquitin (Ub) chaperone Ubiquilin 2 (UBQLN2) cause X-linked forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) through unknown mechanisms. Here, we show that aggregation-prone, ALS-associated mutants of UBQLN2 (UBQLN2ALS) trigger heat stress-dependent neurodegeneration in Drosophila. A genetic modifier screen implicated endolysosomal and axon guidance genes, including...

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Source

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Identifiers

PMID: 37039476
DOI: 10.7554/eLife.84382
PMCID: PMC10147378

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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