Article

Global proteomics of <i>Ubqln</i> 2-based murine models of ALS

2020-02-22

Abstract excerpt

Familial forms of neurodegenerative diseases commonly involve mutation of aggregation-prone proteins or components of the protein degradation machinery that act on aberrant proteins. Ubqln2 encodes a member of the UBL/UBA family of proteasome shuttle factors that is thought to facilitate proteasomal degradation of substrates, and mutation of this gene results in a familial form of ALS/FTD in humans. How Ubqln2 d...

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Literature Corpus work: 4e5d7350-c964-599f-adc0-9e1ac6e0c027
DOI: 10.1101/2020.02.22.956524

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