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Article

UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential.

Biochemical Society transactions - 29 Aug 2025

Matthews Autumn M, Whiteley Alexandra M

Abstract excerpt

Ubiquilins (UBQLNs) regulate cellular protein turnover by shuttling proteins, or 'clients', to the proteasome or autophagy pathways for degradation. Of the five different UBQLN genes in humans, UBQLN2 is the most highly expressed in the nervous system and muscle tissue and has been linked to multiple neurodegenerative diseases. In particular, point mutations of UBQLN2 cause an X-linked, dominant form of...

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Identifiers

PMID: 40663766
DOI: 10.1042/BST20253053
PMCID: PMC12410002

Genes

UBQLN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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