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Article

TRIM9 and TRIM26 Interact with UBQLN2P497H to Modulate Its Proteasomal Degradation.

ACS chemical biology - 20 Feb 2026

Chen Xingyuan, Cao Zhongwen, Liang Xiaochen, Zhao Ting, Wang Yinsheng

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron loss. ALS-linked mutations in UBQLN2 promote protein aggregation and disrupt proteostasis, yet the mutation-specific protein interactomes and their functional relevance remain poorly defined. We employed APEX2 proximity labeling, together with affinity enrichment of biotinylated peptides and...

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Source

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Identifiers

PMID: 41582437
DOI: 10.1021/acschembio.5c00911
PMCID: PMC12867519

Genes

TRIM26
TRIM9
UBQLN2
APEX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRIM9 and TRIM26 Interact with UBQLN2P497H to Modulate Its Proteasomal Degradation.PMID 41582437Read ↗

Global proteomics of Ubqln2-based murine models of ALSSemantic proximity Read ↗

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementiaSemantic proximity Read ↗

Global proteomics of <i>Ubqln</i> 2-based murine models of ALSSemantic proximity Read ↗

Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery.Semantic proximity Read ↗

UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential.Semantic proximity Read ↗

UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD.Semantic proximity Read ↗

ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.Semantic proximity Read ↗

Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregationSemantic proximity Read ↗

ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function.Semantic proximity Read ↗

BAG2 Condensates Couple Proteostasis to CD8 <sup>+</sup> T Cell SurveillanceSemantic proximity Read ↗

Amyotrophic Lateral Sclerosis-Associated Mutants of SOD1 Perturb mRNA Splicing through Aberrant Interactions with SRSF2.Semantic proximity Read ↗

Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD–associated UBQLN2 mutantsSemantic proximity Read ↗

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