Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD.

The FEBS journal - 1 Oct 2022

Lin Brian C, Higgins Nicole R, Phung Trong H, Monteiro Mervyn J

Abstract excerpt

Ubiquilin (UBQLN) proteins are a dynamic and versatile family of proteins found in all eukaryotes that function in the regulation of proteostasis. Besides their canonical function as shuttle factors in delivering misfolded proteins to the proteasome and autophagy systems for degradation, there is emerging evidence that UBQLN proteins play broader roles in proteostasis. New information suggests the proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Amyotrophic Lateral Sclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy-Related Proteins

Share to Cell Cycle Proteins

Share to Frontotemporal Dementia

Share to Mitochondrial Proteins

Share to Proteasome Endopeptidase Complex

Share to Ubiquitins

Source

Open in PubMed Open full text

Identifiers

PMID: 34273246
DOI: 10.1111/febs.16129
PMCID: PMC8761781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UBQLN proteins in health and disease with a focus on UBQLN2 in ALS/FTD.PMID 34273246Read ↗

Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementiaSemantic proximity Read ↗

UBQLN2 in neurodegenerative disease: mechanistic insights and emerging therapeutic potential.Semantic proximity Read ↗

Structure, dynamics and functions of UBQLNs: at the crossroads of protein quality control machinery.Semantic proximity Read ↗

Modeling UBQLN2-mediated neurodegenerative disease in mice: Shared and divergent properties of wild type and mutant UBQLN2 in phase separation, subcellular localization, altered proteostasis pathways, and selective cytotoxicity.Semantic proximity Read ↗

E3 ligase recruitment by UBQLN2 protects substrates from proteasomal degradationSemantic proximity Read ↗

Pathogenic mutations in UBQLN2 exhibit diverse aggregation propensity and neurotoxicity.Semantic proximity Read ↗

ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.Semantic proximity Read ↗

UBQLN2 links proteotoxicity with lipid metabolism in neurodegeneration.Semantic proximity Read ↗

Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2.Semantic proximity Read ↗

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementiaSemantic proximity Read ↗

Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Mutation-dependent aggregation and toxicity in a Drosophila model for UBQLN2-associated ALS.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.