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Mutation profiling of <i>KRAS</i> and <i>BRAF</i> in primary tumors and circulating tumor cells of colorectal cancer patients using PNA-LNA molecular switch

2025-06-03

Abstract excerpt

Identifying KRAS and BRAF mutation status is essential for guiding targeted therapies and enhancing treatment outcomes in colorectal cancer (CRC). This study employs the “PNA-LNA molecular switch” to detect mutations in KRAS codon 12 (c.35G>T/G12V) and BRAF codon 600 (c.1799T>A/V600E) from primary tumours and circulating tumour cells (CTCs) in CRC patients, correlating mutation status with clinicopathological...

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Literature Corpus work
1a2ce6ae-d038-54b0-a582-da472ed69810
DOI
10.1101/2025.06.01.657284
Open publication

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Mutation profiling of <i>KRAS</i> and <i>BRAF</i> in primary tumors and circulating tumor cells of colorectal cancer patients using PNA-LNA molecular switchDOI 10.1101/2025.06.01.657284
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