Article

Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer

2020-12-15

Abstract excerpt

<h4>Background: </h4> KRAS is the most frequently mutated oncogene in cancer, however efforts to develop targeted therapies have been largely unsuccessful. Recently, two small-molecule inhibitors, AMG 510 and MRTX849, have shown promising activity in KRAS G12C-mutant solid tumors. The current study aims to assess the molecular profile of KRAS G12C in colorectal (CRC) and non-small-cell lung cancer (NSCLC) tested i...

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Literature Corpus work: 1e5664ee-fc3c-5224-bdc2-725212c22d4e
DOI: 10.21203/rs.3.rs-108171/v1

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