Article
A novel platform for mutation detection in colorectal cancer using a PNA-LNA molecular switch.
Biosensors & bioelectronics - 1 Jan 2025
Islam Md Sajedul, Aktar Sharmin, Moetamedirad Neda, Xie Nan, Lu Cu Tai, Gopalan Vinod, Lam Alfred K, Shiddiky Muhammad J A
Abstract excerpt
Detection of KRAS mutation in colorectal cancer (CRC) is important in the prediction of response to target therapy. The study aims to develop a novel mutation detection platform called the "PNA-LNA molecular switch" for the detection of KRAS mutation in CRC. We employed the enhanced binding specificity of peptide nucleic acid (PNA) and locked nucleic acid (LNA) in conjunction with a loop-mediated isothermal...
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