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Article

Clinical features associated with NeoRAS wild-type metastatic colorectal cancer A SCRUM-Japan GOZILA substudy.

Nature communications - 13 Jul 2024

Osumi Hiroki, Shinozaki Eiji, Nakamura Yoshiaki, Esaki Taito, Yasui Hisateru, Taniguchi Hiroya, Satake Hironaga, Sunakawa Yu, Komatsu Yoshito, Kagawa Yoshinori, Denda Tadamichi, Shiozawa Manabu, Satoh Taroh, Nishina Tomohiro, Goto Masahiro, Takahashi Naoki, Kato Takeshi, Bando Hideaki, Yamaguchi Kensei, Yoshino Takayuki

Abstract excerpt

"NeoRAS WT" refers to the loss of RAS mutations (MTs) following first-line treatment in metastatic colorectal cancer (mCRC). We evaluate the incidence and clinicopathological characteristics of NeoRAS WT mCRC using next-generation sequencing of plasma circulating tumor DNA. Patients with mCRC enrolled in the GOZILA study initially diagnosed with tissue RAS MT mCRC and received subsequent systemic therapy are...

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Identifiers

PMID: 39003289
DOI: 10.1038/s41467-024-50026-4
PMCID: PMC11246505

Genes

EGFR
KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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