Article
Non-V600 BRAF Mutations Define a Clinically Distinct Molecular Subtype of Metastatic Colorectal Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2017
Jones Jeremy C, Renfro Lindsay A, Al-Shamsi Humaid O, Schrock Alexa B, Rankin Andrew, Zhang Ben Y, Kasi Pashtoon M, Voss Jesse S, Leal Alexis D, Sun James, Ross Jeffrey, Ali Siraj M, Hubbard Joleen M, Kipp Benjamin R, McWilliams Robert R, Kopetz Scott, Wolff Robert A, Grothey Axel
Abstract excerpt
Purpose Molecular diagnostic testing has become an integral part of the evaluation of patients with metastatic colorectal cancer (CRC). Expanded mutational testing, such as next-generation sequencing (NGS), often identifies mutations with unclear clinical or prognostic implications. One such example is BRAF mutations that occur outside of codon 600 (non-V600 BRAF mutations). Methods We conducted this multicenter,...
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