Article
Molecular profiling of metastatic colorectal tumors using next-generation sequencing: a single-institution experience.
Oncotarget - 27 Jun 2017
Gong Jun, Cho May, Sy Marvin, Salgia Ravi, Fakih Marwan
Abstract excerpt
BACKGROUND: Recent molecular characterization of colorectal tumors has identified several molecular alterations of interest that are considered targetable in metastatic colorectal cancer (mCRC). METHODS: We conducted a single-institution, retrospective study based on comprehensive genomic profili...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Colorectal Neoplasms
- Female
- Gene Amplification
- Gene Expression Profiling
- Genetic Predisposition to Disease
- Genetic Variation
- High-Throughput Nucleotide Sequencing
- Humans
- Male
- Middle Aged
- Mutation
- Neoplasm Metastasis
- Neoplasm Staging
- Proto-Oncogene Proteins