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Article

Molecular profiling of metastatic colorectal tumors using next-generation sequencing: a single-institution experience.

Oncotarget - 27 Jun 2017

Gong Jun, Cho May, Sy Marvin, Salgia Ravi, Fakih Marwan

Abstract excerpt

BACKGROUND: Recent molecular characterization of colorectal tumors has identified several molecular alterations of interest that are considered targetable in metastatic colorectal cancer (mCRC). METHODS: We conducted a single-institution, retrospective study based on comprehensive genomic profiling of tumors from 138 patients with mCRC using next-generation sequencing (NGS) via FoundationOne. RESULTS: Overall,...

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Identifiers

PMID: 28178681
DOI: 10.18632/oncotarget.15030
PMCID: PMC5522060

Genes

BRAF
ERBB2
POLE
EGFR
KRAS
MET
NRAS
PTEN
RAF1

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