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Noncoding microdeletion in mouse <i>Hgf</i> disrupts neural crest migration into the stria vascularis, reduces the endocochlear potential and suggests the neuropathology for human nonsyndromic deafness DFNB39

2019-09-23

Abstract excerpt

Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET receptor. HGF stimulates cell proliferation, cell dispersion, neuronal survival and wound healing. In the inner ear, levels of HGF must be fine-tuned for normal hearing. In mouse, a deficiency of HGF expression limited to the auditory system, or over-expression of HGF, cause neurosensory deafness. In human, noncoding variants...

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Literature Corpus work
19ff15bd-bea3-5e99-bd6c-fb01a4e72afc
DOI
10.1101/778365
Open publication

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Noncoding microdeletion in mouse <i>Hgf</i> disrupts neural crest migration into the stria vascularis, reduces the endocochlear potential and suggests the neuropathology for human nonsyndromic deafness DFNB39DOI 10.1101/778365
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