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Article

Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.

PloS one - 1 Jan 2013

Buniello Annalisa, Hardisty-Hughes Rachel E, Pass Johanna C, Bober Eva, Smith Richard J, Steel Karen P

Abstract excerpt

The recessive mouse mutant headbobber (hb) displays the characteristic behavioural traits associated with vestibular defects including headbobbing, circling and deafness. This mutation was caused by the insertion of a transgene into distal chromosome 7 affecting expression of native genes. We show that the inner ear of hb/hb mutants lacks semicircular canals and cristae, and the saccule and utricle are fused...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23457544
DOI: 10.1371/journal.pone.0056274
PMCID: PMC3572983

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