Article

Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome

2023-10-27

Abstract excerpt

<h4>Summary</h4> Mutations in the human genes encoding the endothelin ligand-receptor pair EDN3 and EDNRB cause Waardenburg-Shah syndrome (WS4), which includes congenital hearing impairment. The current explanation for auditory dysfunction is a deficiency in migration of neural crest-derived melanocytes to the inner ear. We explored the role of endothelin signaling in auditory development in mice using neural c...

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Literature Corpus work: 4b3820e0-d31b-5603-be54-fa899d1f52ef
DOI: 10.1101/2023.10.27.564370

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