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Article

Deep Phenotyping of a Mouse Model for Hearing Instability Disorders.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Dec 2024

Johns J Dixon, Adadey Samuel Mawuli, Strepay Dillon, Olszewski Rafal, Hoa Michael

Abstract excerpt

HYPOTHESIS: Hearing instability in Slc26a4 -insufficiency mice may be due to differential expression of genes related to ion homeostasis and activated macrophages. BACKGROUND: Hearing instability (HI) disorders, defined by either hearing fluctuation or sudden loss, remain incompletely understood. Recent studies have described a Slc26a4 (pendrin)-insufficiency mouse model (DE17.5) that offers a genetically driven...

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PMID: 39439049
DOI: 10.1097/MAO.0000000000004345
PMCID: PMC11792085

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