Article

Zfp719 is a transcription factor important for maintenance of hearing in mice

2026-06-15

Abstract excerpt

Zfp719 is a zinc finger transcription factor which, when mutated, results in hearing impairment in mice. Its closest human orthologue, OTK18, has been linked to tinnitus in large human cohorts. Here we present our investigation of the electrophysiological, structural and transcriptional phenotypes in Zfp719 tm1a mutant mice. Homozygotes have near-normal hearing at two weeks old, but lose sensitivity rapidly betw...

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Literature Corpus work: dbf6d170-e42f-5270-b2a9-e2114e514bf4
DOI: 10.64898/2026.06.15.732256

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