Article
Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons.
Genes & development - 15 Dec 1997
Maina F, Hilton M C, Ponzetto C, Davies A M, Klein R
Abstract excerpt
The development of the nervous system is a dynamic process during which factors act in an instructive fashion to direct the differentiation and survival of neurons, and to induce axonal outgrowth, guidance to, and terminal branching within the target tissue. Here we report that mice expressing signaling mutants of the hepatocyte growth factor (HGF) receptor, the Met tyrosine kinase, show a striking reduction of...
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