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Article

Low level of expression of known deafness genes Kcne1, Kcnj10 or Col4a3 is sufficient to maintain hearing in mice.

Hearing research - 1 Sept 2025

Kirwin Darcey A, Treder Nina, Martelletti Elisa, Pentland Daniel R, Kumar Rechal, Ingham Neil J, Steel Karen P

Abstract excerpt

Kcne1, Kcnj10 and Col4a3 are all expressed in the stria vascularis where they serve critical roles in generating the endocochlear potential. Mutations in any of these three genes are linked to human deafness syndromes for which there are currently no treatments. Here, the hearing ability of three mouse lines carrying mutant alleles in these genes (Kcne1tm1a, Kcnj10tm1a and Col4a3tm1a) was investigated to assess...

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Identifiers

PMID: 40645161
DOI: 10.1016/j.heares.2025.109356
PMCID: PMC7619435

Genes

COL4A3
KCNJ10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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