Article

Estrogen-Mediated Suppression of IL-11 as a Hormonal Mechanism Underlying Female Longevity Advantage

2025-11-05

Abstract excerpt

The female longevity advantage—averaging 4-6 years globally—stems from reduced susceptibility to inflammaging, the chronic, low-grade inflammation driving age-related diseases like fibrosis and cardiovascular decline [10]. Interleukin-11 (IL-11), a gp130-family cytokine, has emerged as a pivotal inflammaging mediator: Its genetic or pharmacological inhibition extends mouse median lifespan by 22.5% in males and 25%...

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Literature Corpus work: 4b0846f3-80b0-553a-9041-46140088a19e
DOI: 10.1101/2025.11.03.686437

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