Article
Linkage disequilibrium and haplotype analysis among ten single-nucleotide polymorphisms of interleukin 11 identified by sequencing of the gene.
Journal of human genetics - 1 Jan 2001
Shinohara Y, Ezura Y, Iwasaki H, Nakazawa I, Ishida R, Kodaira M, Kajita M, Shiba T, Emi M
Abstract excerpt
Interleukin (IL11) is a member of the interleukin 6 (IL6)-related cytokine subfamily, which stimulates T cell-dependent development of immunoglobulin-producing B cells. IL11 is also an important paracrine regulator of bone metabolism that induces formation of osteoclasts. In the work reported here, we sequenced the entire IL11 structural gene of 48 alleles in a Japanese test population. These experiments...
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