Article

Epigenetic markers of middle-age: non-linear DNA methylation changes with aging in humans

2025-08-16

Abstract excerpt

<h4>Background</h4> Human DNA is known to exhibit an overall tendency toward demethylation with aging. However, assuming a simple linear relationship between DNA methylation and age does not align with the phenotype of human development and the aging process. This study aimed to investigate the existence of DNA methylation patterns with peaks or troughs at specific ages in addition to simple linear changes. <h4>M...

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Literature Corpus work: a0d763ed-d5ba-53d3-94f4-2ad49eb8825a
DOI: 10.1101/2025.08.14.670237

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