Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

29 Mar 2020

Abstract excerpt

Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the bone morphogenetic protein (BMP) receptor ALK2, causing activation of the SMAD1/5/8 pathway. In this study, we aimed to dissect how activin A and activin B homodimers, and activin AB and AC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heterotopic Ossification and Related Conditions
Share to Kruppel-like factors research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32235336
DOI: 10.3390/biom10040519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 ReceptorsPMID 32235336Read ↗

Activin signaling as an emerging target for therapeutic interventionsSemantic proximity Read ↗

BMPR2 inhibits activin and BMP signaling via wild-type ALK2Semantic proximity Read ↗

BMPR2 inhibits activin- and BMP-signaling via wild type ALK2Semantic proximity Read ↗

Activin receptors in human cancer: Functions, mechanisms, and potential clinical applicationsSemantic proximity Read ↗

Different Immunoregulation Roles of Activin A Compared With TGF-βSemantic proximity Read ↗

Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell InvasionSemantic proximity Read ↗

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and diseaseSemantic proximity Read ↗

Activins, Myostatin and Related TGF-β Family Members as Novel Therapeutic Targets for Endocrine, Metabolic and Immune DisordersSemantic proximity Read ↗

Activins and activin antagonists in hepatocellular carcinomaSemantic proximity Read ↗

Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistanceSemantic proximity Read ↗

A Comprehensive Review Exploring the Role of Bone Morphogenetic Proteins [BMP]: Biological MechanismsSemantic proximity Read ↗

A Survey of Strategies to Modulate the Bone Morphogenetic Protein Signaling Pathway: Current and Future PerspectivesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.