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Article

BMPR2 inhibits activin and BMP signaling via wild-type ALK2

8 May 2018

Abstract excerpt

TGF-β/BMP superfamily ligands require heteromeric complexes of type 1 and 2 receptors for ligand-dependent downstream signaling. Activin A, a TGF-β superfamily member, inhibits growth of multiple myeloma cells, but the mechanism for this is unknown. We therefore aimed to clarify how activins affect myeloma cell survival. Activin A activates the transcription factors SMAD2/3 through the ALK4 type 1 receptor, but...

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PMID: 29739878
DOI: 10.1242/jcs.213512

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