Article

Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess

2021-10-26

Abstract excerpt

<h4>ABSTRACT</h4> In the progression of diabetes, pancreatic islet β-cells respond to increased metabolic demand with functional compensation, followed by pathogenic decompensation of mitochondria-dependent insulin secretion. It is not clear what mechanisms drive, or control, mitochondrial decompensation. Here, we report that anti-apoptotic Bcl-x L maintains mitochondrial integrity in β-cells under non-apoptotic...

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Literature Corpus work: 60d9bd05-fca7-51fe-8ace-7c3470978313
DOI: 10.1101/2021.10.25.465491

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