Evolutionary dynamics of Clostridium difficile over short and long time scales.

doi:10.1073/pnas.0914322107

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Article

Evolutionary dynamics of Clostridium difficile over short and long time scales.

Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2010

He Miao, Sebaihia Mohammed, Lawley Trevor D, Stabler Richard A, Dawson Lisa F, Martin Melissa J, Holt Kathryn E, Seth-Smith Helena M B, Quail Michael A, Rance Richard, Brooks Karen, Churcher Carol, Harris David, Bentley Stephen D, Burrows Christine, Clark Louise, Corton Craig, Murray Vicky, Rose Graham, Thurston Scott, van Tonder Andries, Walker Danielle, Wren Brendan W, Dougan Gordon, Parkhill Julian

Abstract excerpt

Clostridium difficile has rapidly emerged as the leading cause of antibiotic-associated diarrheal disease, with the transcontinental spread of various PCR ribotypes, including 001, 017, 027 and 078. However, the genetic basis for the emergence of C. difficile as a human pathogen is unclear. Whole genome sequencing was used to analyze genetic variation and virulence of a diverse collection of thirty C. difficile...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20368420
DOI: 10.1073/pnas.0914322107
PMCID: PMC2867753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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