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Diversity and Evolution in the Genome of Clostridium difficile.

Clinical microbiology reviews - 1 Jul 2015

Knight Daniel R, Elliott Briony, Chang Barbara J, Perkins Timothy T, Riley Thomas V

Abstract excerpt

Clostridium difficile infection (CDI) is the leading cause of antimicrobial and health care-associated diarrhea in humans, presenting a significant burden to global health care systems. In the last 2 decades, PCR- and sequence-based techniques, particularly whole-genome sequencing (WGS), have significantly furthered our knowledge of the genetic diversity, evolution, epidemiology, and pathogenicity of this once...

Topics

Clostridioides difficile
Clostridium Infections
Evolution, Molecular
Genetic Variation
Genome, Bacterial
Humans
Phylogeny

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 26085550
DOI: 10.1128/CMR.00127-14
PMCID: PMC4475645

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