Article
A high-resolution phenotypic screen identifies regulators of CNS axon diameter in zebrafish.
PLoS biology - 1 Jul 2026
Eichel-Vogel Maria A, Soong Daniel Y H, Sequeira Melody N, Ibenfeldt Maya L A, Marshall-Phelps Katy L H, Bin Jenea M, Lyons David A
Abstract excerpt
The molecular mechanisms underpinning neuronal morphogenesis remain to be fully understood. A powerful step in uncovering the molecular basis of biological processes is the execution of discovery screens in model systems. Here, we employed zebrafish to identify molecules that regulate axon diameter in the central nervous system. Axon diameter can vary by >100-fold, with larger axons exhibiting faster conduction...
Read the complete abstract on PubMedTopics
- Animals
- Zebrafish
- Axons
- Central Nervous System
- Phenotype
- Dopamine
- Signal Transduction