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Article

In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Nov 2012

Plucińska Gabriela, Paquet Dominik, Hruscha Alexander, Godinho Leanne, Haass Christian, Schmid Bettina, Misgeld Thomas

Abstract excerpt

Mitochondria provide ATP, maintain calcium homeostasis, and regulate apoptosis. Neurons, due to their size and complex geometry, are particularly dependent on the proper functioning and distribution of mitochondria. Thus disruptions of these organelles and their transport play a central role in a broad range of neurodegenerative diseases. While in vitro studies have greatly expanded our knowledge of mitochondrial...

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Identifiers

PMID: 23152604
DOI: 10.1523/JNEUROSCI.1327-12.2012
PMCID: PMC6794024

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MARK2

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