Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling Properties

13 Jun 2012

Abstract excerpt

Human interleukin-10 (hIL-10) is a pleiotropic cytokine that is able to suppress or activate cellular immune responses to protect the host from invading pathogens. Epstein-Barr virus (EBV) encodes a viral IL-10 (ebvIL-10) in its genome that has retained the immunosuppressive activities of hIL-10 but lost the ability to induce immunostimulatory activities on some cells. These functional differences are at least...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Cell Function and Interaction
Share to Lymphoma Diagnosis and Treatment
Share to Viral-associated cancers and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22692218
DOI: 10.1074/jbc.m112.376707

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epstein-Barr Virus IL-10 Engages IL-10R1 by a Two-step Mechanism Leading to Altered Signaling PropertiesPMID 22692218Read ↗

Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1Semantic proximity Read ↗

The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptorSemantic proximity Read ↗

Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand dosesSemantic proximity Read ↗

Dual Immune Checkpoint and Cytokine Receptor Modulation by an Engineered Human CTLA-4/IL-10 Bispecific Fusion ProteinSemantic proximity Read ↗

Differential signaling of cmvIL-10 through common variants of the IL-10 receptor 1.Semantic proximity Read ↗

Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses.Semantic proximity Read ↗

Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.Semantic proximity Read ↗

Differential impact of TNFRSF co-stimulation on CD8 <sup>+</sup> T cell cytokine production by feedback control of surface receptor expressionSemantic proximity Read ↗

Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signalingSemantic proximity Read ↗

Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography.Semantic proximity Read ↗

Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineeringSemantic proximity Read ↗

Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.