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Article

The genetic determinants of plasma protein variance across ancestries and effects on cardiometabolic disease risk

2025-11-21

Abstract excerpt

Variance quantitative trait loci (vQTLs), which capture genetic contributions to phenotypic variability, remain underexplored in proteomic studies, particularly across diverse ancestries. We systematically mapped cis -vQTLs for 2,923 plasma proteins in 52,706 UK Biobank participants of European (EUR, N = 45,486), African (AFR, N = 1,336), and Central/South Asian (CSA, N = 934) ancestries, identifying 2,162 vQT...

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Literature Corpus work
195365b3-6532-5426-bc68-2f4e1ecc6aad
DOI
10.1101/2025.11.20.25340688
Open publication

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