Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

doi:10.1038/s41467-018-05512-x

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Article

Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.

Nature communications - 15 Aug 2018

Yao Chen, Chen George, Song Ci, Keefe Joshua, Mendelson Michael, Huan Tianxiao, Sun Benjamin B, Laser Annika, Maranville Joseph C, Wu Hongsheng, Ho Jennifer E, Courchesne Paul, Lyass Asya, Larson Martin G, Gieger Christian, Graumann Johannes, Johnson Andrew D, Danesh John, Runz Heiko, Hwang Shih-Jen, Liu Chunyu, Butterworth Adam S, Suhre Karsten, Levy Daniel

Abstract excerpt

Identifying genetic variants associated with circulating protein concentrations (protein quantitative trait loci; pQTLs) and integrating them with variants from genome-wide association studies (GWAS) may illuminate the proteome's causal role in disease and bridge a knowledge gap regarding SNP-disease associations. We provide the results of GWAS of 71 high-value cardiovascular disease proteins in 6861 Framingham...

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PMID: 30111768
DOI: 10.1038/s41467-018-05512-x
PMCID: PMC6093935

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