Article

Expansion of Functional Regulatory T Cells Using Soluble RAGE Prevents Type 1 Diabetes

2020-01-11

Abstract excerpt

Type 1 diabetes (T1D) is an autoimmune disease with no cure. Therapeutic translation has been hampered by preclinical reproducibility. Here, short-term administration of an antagonist to the receptor for advanced glycation end products (sRAGE) protected against murine diabetes at two independent centers. Treatment with sRAGE increased regulatory T cells (T regs ) within islets, pancreatic lymph nodes and spleen,...

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Literature Corpus work: 192a3550-63ee-5735-aaae-8102e32e9be5
DOI: 10.1101/2020.01.10.902627

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