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Article

Human IL-6RhiTIGIT- CD4+CD127lowCD25+ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.

Clinical immunology (Orlando, Fla.) - 1 Jun 2017

Ferreira Ricardo C, Rainbow Daniel B, Rubio García Arcadio, Pekalski Marcin L, Porter Linsey, Oliveira João J, Waldron-Lynch Frank, Wicker Linda S, Todd John A

Abstract excerpt

To date many clinical studies aim to increase the number and/or fitness of CD4+CD127lowCD25+ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define the phenotype and function of Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population of CD4+CD127lowCD25+ TIGIT- T cells distinguished by...

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Identifiers

PMID: 28284938
DOI: 10.1016/j.clim.2017.03.002
PMCID: PMC5471606

Genes

FOXP3
RORC
TIGIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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