Article
Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jul 2013
Jiang Xiaomo, Hao Huai-Xiang, Growney Joseph D, Woolfenden Steve, Bottiglio Cindy, Ng Nicholas, Lu Bo, Hsieh Mindy H, Bagdasarian Linda, Meyer Ronald, Smith Timothy R, Avello Monika, Charlat Olga, Xie Yang, Porter Jeffery A, Pan Shifeng, Liu Jun, McLaughlin Margaret E, Cong Feng
Abstract excerpt
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However, clinical development of these molecules is challenging because of the lack of a genetic strategy to identify human tumors dependent on ligand-induced Wnt/β-catenin signaling. Ubiquitin E3 ligase ring finger 43 (RNF43) has been suggested as a negative regulator of Wnt signaling, and...
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